L-Triiodothyronine(T3)

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L-Triiodothyronine(T3)
CAS NO:55-06-1
EINECS : 200-223-5
Chemical name:3,3',5-Triiodo-L-thyronine, sodium salt
Molecular formula:C15H12I3NO4
Molecular Weight:650.97
Molecular Structure:

Content:(%):99
Boiling point:205°C
water-solubility:4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
Description :
A . Treatment of depressive disorders:
The addition of triiodothyronine to existing treatments such as SSRIs is one of the most widely studied augmentation strategies for refractory depression,however success may depend on the dosage of T3. A long-term case series study by Kelly and Lieberman of 17 patients with major refractory unipolar depression found that 14 patients showed sustained improvement of symptoms over an average timespan of two years, in some cases with higher doses of T3 than the traditional 50 μg required to achieve therapeutic effect, with an average of 80 μg and a dosage span of 24 months; dose range: 25-150 μg.The same authors published a retrospective study of 125 patients with the two most common categories of bipolar disorders II and NOS whose treatment had previously been resistant to an average of 14 other medications. They found that 84% experienced improvement and 33% experienced full remission over a period of an average of 20.3 (standard deviation of 9.7). None of the patients experienced hypomania while on T3.

B . Use as a fat loss supplement:
3,5-Diiodo-L-thyronine and 3,3'-diiodo-L-thyronine are used as ingredients in certain over-the-counter fat-loss supplements, designed for bodybuilding. Several studies have shown that these compounds increase the metabolization of fatty acids and the burning of adipose fat tissue in rats.

Applications:
Intended use
Immunoassay for the in vitro quantitative determination of free triiodothyronine in human serum.

Summary
Triiodothyronine is one of the thyroid hormones present in serum which regulates metabolism. Determination of this hormone
concentration is important for the diagnostic differentiation of euthyroid, hyperthyroid, and hypothyroid states. The major fraction of total triiodothyronine is bound to the transport proteins (TBG, prealbumin, albumin). Free triiodothyronine (fT3) is the
physiologically active form of the thyroid hormone triiodothyronine (T3). The determination of free T3 has the advantage of being independent of changes in the concentrations and binding properties of the binding proteins; additional determination of a binding parameter (T-uptake, TBG) is therefore unnecessary. (1, 2, 3) In normal thyroid function, as the concentrations of the carrier proteins alter, the total T3 level changes so that the FT3 concentration remains constant. (4) Thus, measurements of FT3
concentrations correlate more reliably with clinical status than total T3 levels. For example, the increase in total T3 levels associated with pregnancy, oral contraceptives and estrogen therapy result in higher total T3 levels while the FT3 concentration
remains basically unchanged. (5) In addition, it has been found that the mean FT3 value has a gradient decreasin from young to older. (6)

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