Testosterone Undecanoate

Product name:Testosterone Undecanoate
Other name:Andriol
CAS register number:5949-44-0
EINECS: 227-712-6
Molecular formula:C30H48O3
Molecular weight:456.70
Assay:97.0%~103.0%
Appearance:White crystalline powder
Package:1kg/aluminium foil bag or as required
Usage:can be used as pharmaceutical material
2. Product description

Andriol first became available in the early 1980′s. This compound contains 40 mg of testosterone undecanoate, based in oil (oleic acid) and sealed inside a capsule.
Subtracting the ester weight, this equates to a dosage of approximately 25mg of raw testosterone per cap. The design of this steroid is quite different from that of most oral steroids.

Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the "first pass".
This process leaves very little steroid intact, basically deactivating the drug. Adding a methyl group (c-17 AA) to the structure is one way to protect it from this process, however stress is also placed on the liver as a result.

In some instances this stress can lead to actual damage to liver tissues, so the designers of this steroid sought another way to protect the testosterone molecule. With Andriol, this was accomplished by making a form of testosterone that would be absorbed through the lymphatic system. This is due to its high fat solubility brought about by the ester, and its suspension in oil.

Having the compound absorbed this way was thought to be very advantageous, as it allows the steroid to bypass the destructive first-pass through liver. This should permit the compound to enter the blood stream intact, without the need for a harsh chemical alteration. The ester breaks off once it is in circulation of course, yielding free active Pharmacokinetics of Oral Testosterone. In design this steroid appears to be undecanoate that of a completely liver safe and orally active form of testosterone.

Character: White crystalline powder.
Usage: Male hormone, for male sexual dysfunction, aplastic anemia

Applications:

Testosterone undecanoate or testosterone undecylate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive, testosterone undecanoate is sold and distributed under the brand names Andriol, understor, nebido, pantestone, restandol.

Andriol is a version of the anabolic steroid testosterone undecanoatedeveloped by the pharmaceutical company organon, testosterone is said to enter the body as a fat through the lymphatic system, experience from user indicates that in dose of less than 240mg per day, effects are negligible, except at every onset of use, while even in higher dose, effects are still minimal, testosterone undecanoate is therefor thought that most of the steroid is somehow not making it into the blood stream.

Testosterone undecanoate or testosterone undecylate is an ester of testosterone. This hormone is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.


3. COA



Test Items Specification Test Results

Appearance White or almost white crystalline powder Conform

Loss on drying ≦0.5% 0.24%

Optical rotation +68°~+72° 71.0°

Melting Point 60~65°C 61-63°C

(HPLC)Assay 97-103.0% 98.65%

Free acid 0.5%max 0.35%

Conclusion The aboye product conforms analysis standard




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