Gamma-Butyrolactone (γ-butyrolactone or GBL)

Gamma-Butyrolactone (γ-butyrolactone or GBL)
Product Description:
Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.

GBL has been found in extracts from samples of unadulterated wines.[3] This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff.

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB.
The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood.[7][8] Animals which lack these enzymes exhibit no effect from GBL.[7] GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.

Reach me:
toni at ycgmp dot com
Tel: +86-18872220727

Send product request

To: Hubei Jiaye Steroid
Your E-mail:
Message text:

Send to other suppliers

Other supplier products

Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride
Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride CAS: 74874-08-1 MF: C15H28N6O5.HCl MW: 408.88 Product...
Bimatoprost Bimatoprost I am Lisa, : lisa at ycgmp dot com, Skype:poisedtoni, Tel: +86-18872220727, you can add me on Whatsapp if you are using that. Contact L...
Methenolone Enanthate
Methenolone Enanthate Methenolone Enanthate Molecular Formula C27H42O3 Molecular Weight 414.6206 CAS Registry Number 303-42-4 EINECS 206-141-6 Density 1.05g/cm3 Boiling ...
Ingredient of Weekend Pill Tadalafil
Ingredient of Weekend Pill Tadalafil Ingredient of Weekend Pill Tadalafil What is tadalafil? Tadalafil CAS: 171596-29-5 Tadalafil under the name of Cialis is used to treat erectile dys...
Nandrolone Decanoate
Nandrolone Decanoate Nandrolone Decanoate Molecular Formula C28H44O3 Molecular Weight 428.6472 CAS Registry Number 360-70-3 EINECS 206-639-3 Density 1.04g/cm3 Melting p...
All supplier products

Same products

Top Quality Potassium Humate powder or flakes from Leonardite Organic Fertilizer
Top Quality Potassium Humate powder or flakes from Leonardite Organic Fertilizer Seller: XI'AN SUNMATTE TECHNOLOGY.CO.,LTD SpecificationHumic acid (dry basis)70%min.Fulvic  acid (dry basis)15%min.Potassium (as K2O)8%min....
Zeolite Suncream Additive
Zeolite Suncream Additive Seller: Gt2016 Product Name: Zeolite Suncream Additive China Food and Drug Administration has listed Zeolite in ...
Zeolite Beauty Soap Additive
Zeolite Beauty Soap Additive Seller: Gt2016 Product Name: Zeolite Beauty Soap Additive Product Feature: ●Effect: cleaning, sterilization, be...
DL-Methionine 99%
DL-Methionine 99% Seller: Oriental Yuzun Agricultural Development CO., LIMITED DL-Methionine(Feed Grade) Common names Methionine, dl-methionineProperty: DL-Methionine:The ...
Modified Soya Lecithin
Modified Soya Lecithin Seller: Oriental Yuzun Agricultural Development CO., LIMITED Modified Soya Lecithin Common names Modified Soya Fat, Modified soybean phospholipids, Modifie...