Treating Sexual Dysfunction Bremelanotide aka PT-141

Treating Sexual Dysfunction Bremelanotide aka PT-141
Bremelanotide was developed from the peptide hormone Melanotan II which underwent testing as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects.

Structure
Bremelanotide is a cyclic hepta-peptide lactam analog of alpha-melanocyte-stimulati
ng hormone (alpha-MSH) that activates the melanocortin receptors MC3-R and MC4-R in the central nervous system. It has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). It is a metabolite of Melanotan II that lacks the C-terminal amide function.

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