Oral Steroid Known as Anabol, Danabol, Averbol, Dianabol, Metandienone, Methandienone

Oral Steroid Known as Anabol, Danabol, Averbol, Dianabol, Metandienone, Methandienone
1. PHYSICO-CHEMICAL PROPERTIES
1.1 Origin of the substance
Naturally-occuring anabolic steroids are synthesised in
the testis, ovary and adrenal gland from cholesterol via
pregnenolone. Synthetic anabolic steroids are based on the
principal male hormone testosterone, modified in one of three
ways:
alkylation of the 17-carbon
esterification of the 17-OH group
modification of the steroid nucleus
1.2 Chemical structure
Chemical Name:
17beta-Hydroxy-17alpha-methylandrosta-1,4-dien-3-one.
Molecular Formula: C20H28O2
Molecular Weight: 300.4
2. USES
2.1 Indications
2.1.1 Indications
Anabolic agent; systemic
Anabolic steroid
Androstan derivative; anabolic steroid
Estren derivative; anabolic steroid
Other anabolic agent
Anabolic agent for systemic use; veterinary
Anabolic steroid; veterinary
Estren derivative; veterinary
2.1.2 Description
The only legitimate therapeutic indications for
anabolic steroids are:
(a) replacement of male sex steroids in men who have
androgen deficiency, for example as a result of loss
of both testes
(b) the treatment of certain rare forms of aplastic
anaemia which are or may be responsive to anabolic
androgens.
(c) the drugs have been used in certain countries to
counteract catabolic states, for example after major
trauma.
2.3 Contraindications
Known or suspected cancer of the prostate or (in men)
breast.
Pregnancy or breast-feeding.
Known cardiovascular disease is a relative contraindication.
3. ROUTES OF EXPOSURE
3.1 Oral
Anabolic steroids can be absorbed from the
gastrointestinal tract, but many compounds undergo such
extensive first-pass metabolism in the liver that they are
inactive. Those compounds in which substitution of the 17-
carbon protects the compound from the rapid hepatic
metabolism are active orally
There are preparations of testosterone that can be taken
sublingually.
3.2 Inhalation
Not relevant
3.3 Dermal
No data available
3.4 Eye
Not relevant
3.5 Parenteral
Intramuscular or deep subcutaneous injection is the
principal route of administration of all the anabolic
steroids except the 17-alpha-substituted steroids which are
active orally.
4. Pharmacodynamics
Anabolic steroids bind to specific receptors
present especially in reproductive tissue, muscle and
fat. The anabolic steroids
reduce nitrogen excretion from tissue breakdown in
androgen deficient men. They are also responsible for
normal male sexual differentiation. The ratio of
anabolic ("body-building") effects to androgenic
(virilizing) effects may differ among the members of
the class, but in practice all agents possess both
properties to some degree. There is no clear evidence
that anabolic steroids enhance overall athletic
performance.

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