Rat Plasma kallikrein(KLKB1) ELISA kit

Product Name:
Rat Plasma kallikrein(KLKB1) ELISA kit
Product Type : ELISA Kit
Code : CSB-EL012461RA
Size : 96T,5×96T,10×96T
Uniprot NO. : P14272
Abbreviation : KLKB1
Protein Biological Process 1 : Blood Coagulation
Alias : KLK3, PPK, Fletcher factor|kininogenin|plasma kallikrein B1|plasma kallikrein heavy chain|plasma kallikrein light chain
Species : Rat
Protein Biological Process 3 : Blood coagulation
Sample Types : serum, plasma, tissue homogenates
Detect Range : 7.8 ng/ml-500 ng/ml
Sensitivity : 1.95 ng/ml
Assay Time : 1-5h
Sample Volume : 50-100ul
Detection Wavelengt : 450 nm
Availability : 5-7 working days
Research Area : Cell Biology
Protocol :
Instructions
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target details : Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.




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