Recombinant human Extracellular calcium-sensing receptor

Product Name:
Recombinant human Extracellular calcium-sensing receptor
Product Type : Recombinant Protein
Code : CSB-EP004558HU
Size : 1mg
Research Area : Neuroscience
Source : E.coli
Gene Names : CASR GPRC2A PCAR1
Expression Region : 20-612aa
Product Info : GST-tag
Mol. Weight : 93.8kD
Protein Description : Extracellular domain
Target details : This protein is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

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