Desmopressin Acetate Sequence

Product Name Desmopressin Acetate
Sequence
Cas No. 16789-98-3
Molecular Formula C46H64N14O12S2
Molecular Weight 1069.24
Purity (HPLC) 98.0%min.
Appearance? White powder
Single Impurity (HPLC)? 0.5%max
Amino Acid Composition? ±10% of theoretical
Peptide Content (N%) ≥80.0%
Water Content (Karl Fischer)? ≤8.0%
Acetate Content (HPIC) ≤12.0%
MS (ESI) Consistent
Mass Balance? 95.0~105.0%


Description:

Desmopressin (trade names: DDAVP, DesmoMelt, Minirin, Minirin Melt, Octim, Stimate) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as an oral or sublingual tablet. Physicians prescribe desmopressin most frequently for treatment of diabetes insipidus, bedwetting, or nocturia.

Application:

Doctors prescribe desmopressin frequently for treatment of nocturnal enuresis (bedwetting). It is usually prescribed in the form of oral desmopressin acetate, DDAVP. Patients taking DDAVP are 4.5 times more likely to sleep without disruption compared with placebo.
Desmopressin can be used to promote the release of von Willebrand factor (with subsequent increase in factor VIII survival secondary to vWF complexing) in patients with coagulation disorders such as von Willebrand disease, mild hemophilia A (factor VIII deficiency), and thrombocytopenia. It can be used with uremic induced platelet dysfunction. It is not effective in the treatment of hemophilia B (factor IX deficiency), severe hemophilia A, or von Willebrand 2B.




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