Isotretinoin


Isotretinoin

Isotretinoin
Synonym: 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Assay: 99%
Appearance: Orange Crystal Powder
Specification: CP
Chemical Property: The melting point of 174 ~ 175 Centigrade. UV maximum absorption: 354nm ( 39800). Acute toxicity of LD50 (20 days) mice, rats by intraperitoneal injection of:904901 (mg/kg); 3389 > 4000 oral.
Usage of Tretinoin:
Isotretinoin or 13-cis retinoic acid is a very effective medication for the treatment of acne . It is a retinoid; this means it is derived from vitamin-A (retinoic acid). The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically.

Isotretinoin Description

1,Isotretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.

2 Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.


Isotretinoin Function
1.Isotretinoin's main indication is for the treatment of severe cystic acne vulgaris. Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.

2.It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.

3.Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used due to potentially severe side effects. In a small-scale study, low dose oral isotretinoin showed considerable efficacy;

4.Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for RCA of the cervix. Not many studies have been conducted to further confirm its effectiveness. In most countries this therapy is currently unapproved and only used if other therapies failed.

ning:0pt'>0.6EU/mg



Application:

1. Medical applications: the lack of nutrition of the elderly, thin, for severe burns and had the operation people.

2. Sports purpose: promote muscle growth, increased training and endurance training load, it has never been proved.

3. Adaption: Trauma, chronic infection, malnutrition and wasting disease and All kinds of refractory anemia.

 




Send product request

To: Hubei Yuancheng Gongchunag Tech
Your E-mail:
Message text:


Send to other suppliers

Other supplier products

17α-Methyl-1-testosterone  Methyltestosterone
17α-Methyl-1-testosterone Methyltestosterone Name: 17α-Methyl-1-testosterone Methyltestosterone(17-alpha-methyl-testosterone) Alias:17a-Methyl-1-Testosterone; 17b-hydroxy-17a-methyl-5a-a...
Muscle Building Durabolin Steroids Nandrolone Cypionate
Muscle Building Durabolin Steroids Nandrolone Cypionate Muscle Building Durabolin Steroids Nandrolone Cypionate Product name Nandrolone cypionate Other name Nortestosterone cypionate; Nandrolone cyclopen...
Nandrolone Undecylate
Nandrolone Undecylate Nandrolone Undecylate English Name: 17beta-Hydroxyestr-4-en-3-one 17-undecanoate CAS number: 862-89-5 EINECS:212-729-3 Molecular formula: C29H46O3 ...
 Estriol 50-27-1
Estriol 50-27-1 Estriol 50-27-1 Standards:USP27 CAS:50-27-1 Packing:Foil bag Details Package: as requirements or normal package Brandname: nanjian,hezhong Origin :...
 N-Acetyl-Cysteine
N-Acetyl-Cysteine N-Acetyl-Cysteine Alias: N-Acetyl L-Cysteine Other: Pharmaceutical Material Type: Raw Material CAS: 616-91-1 Formula: Medicines Molecular Wei...
All supplier products

Same products

Order TOP QUALITY CALIBER Seller: KeystoneMeds FROM TRUSTED MANUFACTURERS TOP QUALITY REGULAR SUPPLIES OF QUALITY PHARMACEUTICAL MEDICATIONS AND...
Camera Rodder Pipeline and underwater video equipment
Camera Rodder Pipeline and underwater video equipment Seller: Wan Qi electric power equipment factory Introduce   TRACEABLE DUCT RODDER containing metal lines, can be used to detect equipment ea...
1756-OB16D	 1747-L541
1756-OB16D 1747-L541 Seller: MOORE (HK) AUTOMATION LIMITED 1756-OB16D 1747-L541 【NEW+ORIGINAL+ONE YEAR WARRANTY+DISCOUNT】 Contact:Jessica Q Q:2851195444 E...
1770-KF2       1756-ENBT
1770-KF2 1756-ENBT Seller: MOORE (HK) AUTOMATION LIMITED 1770-KF2 1756-ENBT 【NEW+ORIGINAL+ONE YEAR WARRANTY+DISCOUNT】 Contact:Jessica Q Q:2851195444 Ema...
1770-KF2       1756-ENBT
1770-KF2 1756-ENBT Seller: MOORE (HK) AUTOMATION LIMITED 1770-KF2 1756-ENBT 【NEW+ORIGINAL+ONE YEAR WARRANTY+DISCOUNT】 Contact:Jessica Q Q:2851195444 Ema...