Tranexamic acid

Tranexamic acid

Alias: Amstat
Synonym: TIMTEC-BB SBB006715; TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID; Trans-4-aminomethylcyclohexane-1-carboxylate; TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID; TRANEXAMIC ACID; Amstat; Amcha; Amikapron
CAS: 1197-18-8
MF: C8H15NO2
MW: 157.21
EINECS: 214-818-2
Assay: 99%
Specification: CP
Appearance: White powder
Chemical Property: To aminomethylbenzoic acid tranexamic acid derivatives, is a kind of antifibrinolytic drugs to stop bleeding, hemostasis and aminocaproic acid, tranexamic acid, but the effect is stronger, strength is 7 ~ 2 amino acid 10 times, aminomethylbenzoic acid, and similar in toxicity.

Description:
Tranexamic acid is a synthetic derivative of the amino acid lysine.Tranexamic acid (commonly marketed in tablet form as Lysteda and in IV form as Cyklokapron in the U.S. and as Transamin,Transcam in Asia, and Espercil in South America) is often prescribed for excessive bleeding.

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is the basic framework for the formation of a blood clot in hemostasis.Tranexamic acid has roughly 8 times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid.

Usage:
1. Hemostatic, significant effect on traumatic bleeding, preoperative prophylactic medication can decrease operation hemorrhage.
2. The chemical structure of tranexamic acid and lysine, competitive inhibition of plasminogen to fibrin adsorption, to prevent their activation, protect the fiber protein was not degraded by the enzyme and dissolved, ultimately achieve hemostasis effect.
3. All applicable in the treatment of acute or chronic, localized or systemic primary fibrinolysis hyperfunction caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hypertrophy of the prostate, hemophilia hemorrhage, pulmonary tuberculosis hemoptysis, bleeding in the stomach, liver, lung, spleen and other organs of hemorrhage after operation
4. The clinical effect of tranexamic acid on insect bites, eczema and dermatitis, simple purpura, chronic urticaria, artificial sex urticaria, rash and drug poisoning effect, also have certain effects on erythroderma, scleroderma, SLE, erythema multiforme, herpes zoster and alopecia areata, curative effect of hereditary angioedema is also good.

 




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