Mifepristone


Mifepristone
Molecular Formula:C29H35NO2
CAS Registry Number:84371-65-3
Synonyms:Estra-4,9-dien-3-one,11-[4-(dimethylamino)- phenyl]-17-hydroxy-17-(1-propynyl)-,(11a,- 17a)-; Mifepristone [USAN:BAN:INN]; 17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one; Mifeprex; Mifepristonum [Latin]; R 38486; RU 38486; 11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on; Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-, (11b,17b)-; Prestwick_570; Mifegyne; (11beta,17beta)-11-(4-(Dimethylamino)-phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; RU-486; RU486; 11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on; RU 486-6; 17-(1-propynyl)estra-4,9-dien-3-one;

Chemical Properties
Appearance:Pale Yellow Solid
Molecular Weight:429.5937
Density:1.18 g/cm3
Boiling Point:628.6 °C at 760 mmHg
Melting Point:195-198°C
Flash Point:334 °C
Storage Temperature:2-8°C
Refractive index:1.623
Solubility:Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Biological Activity:Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.
Stability:Stable at normal temperatures and pressures.
Usage:A progesterone receptor antagonist with partial agonist activity. Abortifacient.




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