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Moxifloxacin hydrochloride 

Chemical name: 1- cyclopropyl -7- (S, S-2,8- diazo bicyclic [4.3.0] nonane -8- based) -6- fluoro -8- methoxy -1,4- 

Two hydrogen -4- oxygen -3- quinoline carboxylic acid hydrochloride 

Molecular formula: C21H24FN3O4 HCI 

Molecular weight: 437.9. 

CAS:186826-86-8 

Quality standards: EP6.0 content: 99.5%. Miscellaneous: total less than 0.5% single impurity: less than 0.1% 

Other impurities: A, B, C, D, E and other impurities not detected. 

Mechanism of action: moxifloxacin hydrochloride is a broad spectrum and antimicrobial activity of 8- methoxy quinolone antibacterial drug with. 

In vitro showed against gram positive bacteria, gram negative bacteria, anaerobic bacteria, acid fast bacteria and atypical organisms such as Mycoplasma, chlamydia and Legionella have broad-spectrum antibacterial activity. 

Moxifloxacin hydrochloride antibacterial mechanism for the interference of II, IV topoisomerase. Topoisomerase is to control the DNA topology and in DNA replication, repair and transcription of key enzyme. 

Moxifloxacin hydrochloride bactericidal curves show, moxifloxacin hydrochloride is a concentration dependent bactericidal activity. Minimum bactericidal concentration and minimum inhibitory concentration is consistent. Moxifloxacin hydrochloride on b- lactam and a macrolide antibiotic resistant bacteria are effective. 

Indications: suffering from upper and lower respiratory tract infection in adult (≥ 18 years), such as acute sinusitis, acute exacerbation of chronic bronchitis, community acquired pneumonia, and skin and soft tissue infection 




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