Estradiol

Quick Detail:

Product Name:Estradiol;beta-estradiol-16;Estradiol;estradiol
CAS:50-28-2
EINECS:200-023-8
Molecular Weight:272.38
Molecular Formula:C18H24O2
Appearance:White Crystalline Powder
Usage:Estradiol by estrogen in the treatment of skin absorption agent

Description:

17α-Estradiol is a less feminizing isomer of the potent hormonal estrogen, 17β-estradiol. 17α-Estradiol is an orally active small molecule with conflicting reports of efficacy in preclinical models of degenerative diseases. A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease. Several studies have established an antioxidant effect of 17α-estradiol in humans.

Applications:

1). 17α-Estradiol is a less feminizing isomer of the potent hormonal estrogen, 17β-estradiol. 17α-Estradiol is an orally active small molecule with conflicting reports of efficacy in preclinical models of degenerative diseases. A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease. Several studies have established an antioxidant effect of 17α-estradiol in humans.

2). The sodium salt of 17α-estradiol 3-sulfate is a minor component (2.5–9.5%) of several widely marketed estrogen hormone replacement products, such as Premarin, that are approved by the U.S. Food and Drug Administration and have been prescribed and studied in women and men for more than 65 years. Most of the more than 100 published reports on the neurological effects of feminizing estrogens found positive responses in at least one measure relating to cognition or prevention and treatment of AD, notwithstanding the negative results in the Women's Health Initiative studies.