Gonadorelin Acetate

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Product Name

Gonadorelin Acetate

Sequence

Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Cas No.

71447-49-9

Molecular Formula

C55H75N17O13

Molecular Weight

1182.3

Purity (HPLC)

98.0%min.

Appearance

White powder

Single Impurity(HPLC)

0.5%max

Amino Acid Composition

±10% of theoretical

Peptide Content(N%)

≥80.0%

Water Content(Karl Fischer)

≤8.0%

Acetate Content(HPIC)

≤10.0%

Specific Rotation (20/D)

-55.0~-65.0°(c=1 1%HAc)

MS(ESI)

Consistent

Mass Balance

95.0~105.0%

 

 

 

Usage: Mainly used for prostate cancer. 

Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. 
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease. 
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.




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