SR9011

SR9011
Cas No 1379686-29-9
Formula C23H31ClN4O3S
Molucelar weight 479.03524

Description
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.




Send product request

To: Hubei Yuancheng Gongchaung Tech Co.,LTD
Your E-mail:
Message text:


Send to other suppliers

Other supplier products

 canrenone  CAS NO.976-71-6
canrenone CAS NO.976-71-6 canrenone CAS NO.976-71-6 Name: Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)- Formula: C22H28O3 Molecular Weight: 340.46...
betamethasone 17-valerate betamethasone 17-valerate Synonyms:betamethasone pentanoate; Betamethasone Valerate; 1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-di...
 Anti-Estrogen Powder 107868-30-4 Exemestane
Anti-Estrogen Powder 107868-30-4 Exemestane Exemestane (Steroids) Aromasin Anti-Estrogen Powder 107868-30-4 Exemestane Exemestane 107868-30-4 Anabolic Steroid Powder Aromasin Powder White Exe...
 Oxolinic acid
Oxolinic acid Oxolinic acid CAS No.: 14698-29-4 EINECS No.: 238-750-8 Purity: 99% Molecular Weight: 261.2301 MF: C13H11NO5 Appearance: white crystalline powder M...
 Succimer
Succimer Succimer Alias: succimer; dimercaptosuccinic acid; between 2,3 dimercaptosuccinic acid; MESO-2,3- dimercaptosuccinic acid; meso 2,3 dimercaptosucc...
All supplier products

Same products

gift box Seller: Dongguan Avatargifts Co.,Ltd Welcome to order
gift box Seller: Dongguan Avatargifts Co.,Ltd Welcome to order
Feellife unique ejuice Mango yogurt with child proof bottle
Feellife unique ejuice Mango yogurt with child proof bottle Seller: Feellife Health Inc. We are TOP eliquid factory with cheaper price but higher quality Description: 1. ISO9001,FDA,TUV,...
Feellife premium eliquid Macaron for refill ecigarette
Feellife premium eliquid Macaron for refill ecigarette Seller: Feellife Health Inc. We are TOP eliquid factory with cheaper price but higher quality Description: 1. ISO9001,FDA,TUV,...
Feellife great eliquid dessert flavor Opera
Feellife great eliquid dessert flavor Opera Seller: Feellife Health Inc. We are TOP eliquid factory with cheaper price but higher quality Description: 1. ISO9001,FDA,TUV,...