Spironolactone

Spironolactone
EINECS:200-133-6
Molecular Formula:C24H32O4S
CAS Registry Number:52-01-7
Synonyms:Alderon; 3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alph a.-yl)propionic acid lactone; Uractone; Spiro(17H-cyclopenta(a)phenauthrene-17,2-(3H)-furan); Xenalon; Pregn-4-ene-21-carboxylic acid,7-(acetylthio)-17-hydroxy-3-oxo-,?- lactone,(7R,17R)-; Aldactone; 17.alpha.-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7.alpha.-mercapto-3-oxo-, .gamma.-lactone, acetate; Euteberol; Prestwick_449; Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-; Spironolactone A; Urusonin; Verospirone; SC 9420; SC 15983; Spiro(17H-cyclopenta(a)phenanthrene-17,2(5H)-furan), pregn-4-ene-21-carboxylic acid deriv.; Spiro-Tablinen; Spirolang; Spironolactone [BAN:INN:JAN]; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone; 7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone (9CI); 496916-40-6; Spironolactonum [INN-Latin]; Aldactone A; Aldactazide (TN); Spiroctan; 3-(3-Oxo-7-alpha-acetylthio-17-beta-hydroxyandrost-4-en-17-beta-yl)propionic acid lactone; 7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone; Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, g-lactone, (7a,17a)-; Verospiron;

Chemical Properties
Appearance:White powder.
Molecular Weight:416.57
Density:1.24g/cm3
Boiling Point:597℃ at 760mmHg
Melting Point:198-207℃
Flash Point:302.3℃
Alpha:-37 ° (C=1, CHCL3)
Storage Temperature:Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Refractive index:-36 ° (C=1, CHCl3)
Solubility:practically insoluble
Biological Activity:Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Stability:Stable under normal temperatures and pressures.
Usage:It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypok.

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