Tamoxifen Citrate (Nolvadex )

• 

Product Name:Tamoxifen Citrate(Nolvadex )

Synonyms:1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen

CAS:54965-24-1

MF:C32H37NO8

MW:563.64

EINECS:259-415-2

MP:140-144 °c

Storage Temp. :2-8°C

Water Solubility:slightly soluble

Chemical Properties:white to off-white powder

Biological Activity:Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.

Uses:For the treatment of advanced and recurrent breast cancer and ovarian cancer, etc.

Clinical Application:

1). Treatment of breast cancer.

2). Prevention of breast cancer.

3). Anti-tumor and anti-multidrug resistance.

By reducing membrane negotiability and enhancing rigidity of inter-cell binding site, Tamoxifen citrate can reduce concentration and activity of cancer metastasis promoter and various activating enzymes, so as to inhibit or hinder growth and metastasis of cancer cell. In addition, it can promote cells surrounding tumor focus to secrete a negative growth factor - transforming growth factor TGF- G, inhibiting multiply indefinitely of cancer cells; inhibiting oxidative damage of DNA bases which is caused by hydrogen peroxide generated from human neutrophils. So except for breast cancer, it is good for treatment and prevention of other malignant neoplasms, and is used for treatment of brain tumors, liver cancer, prostate cancer, etc. In addition, Tamoxifen citrate can reduce release effect of membrane P170 glycoprotein through reducing membrane negotiability, improving intracellular effective concentration of cytotoxic drug and reducing drug resistance 4).Heart protection.

Other supplier products

	Epiandrosterone steroid hormone	Product Name:Epiandrosterone Synonyms:trans-androsterone;(3S,5S,8R,10S,13S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one...
	Testosterone Sustanon 250	Testosterone Sustanon 250 Alias: omnadren; sustanon; omnis; testosterone blend; mixed testosterone Sustanon is mixed with testosterone Main ingr...
	Fluoxymesterone/ Halotestin	Product Name:Fluoxymesterone Synonyms:11-beta,17-beta-Dihydroxy-9-alpha-fluoro-17-alpha-methyl-4-androster-3-one;17-alpha-methyl-9-alpha-fluoro-11...
	Mestanolone	Product Name:Mestanolone Synonyms:Methyldihydrotestosterone;Mestaline;Methylandrostanolone; 3-Keto-17b-Hydroxy-17a-Methyl-5a-Androstane;17alpha-M...
	Oxandrolone (Anavar) anabolic steroid to promote muscle growth and treat osteoporosis	Product Name:Oxandrolone (Anavar) Synonyms:17beta-Hydroxy-17-Methyl-2-Oxa-5alpha-Androstan-3-One;5-Alpha-Androstan-2-Oxa-17-Alpha-Methyl-17 Beta-O...

Same products

	Peptide Technology Cooperation & Transfer	Seller: PeptiOrigin Biotechnology Co., Ltd.	Peptide Technology Cooperation & Transfer Driving Innovation Through Strategic Partnerships ...
	Recombinant Human Fibroblast Growth Factor-basic	Seller: Hangzhou NeuroPeptide Biological Science and Technology Incorporation, Ltd	Physical Appearance:Freeze-dried powder Formulation:5mMPB(pH7.4) before freeze-drying TheorypI:...
	Recombinant Staphylococcal Protein A	Seller: Hangzhou NeuroPeptide Biological Science and Technology Incorporation, Ltd	TheorypI:5.10 Resources:Escherichia coli(E. coli) Purity:≥95% Storage condition:-20℃ Stora...
	NuPerley Core 700	Seller: Hangzhou NeuroPeptide Biological Science and Technology Incorporation, Ltd	NuPerley Core 700 Matrix：Rigid agarose microsphere Ligand：n-octylamine Particle size, d50：~90 ...
	Q NUPharose Fast Flow	Seller: Hangzhou NeuroPeptide Biological Science and Technology Incorporation, Ltd	Matrix：6% Cross-linked agarose Ligand：Quaternary ammonium salt, -CH2CH(OH)CH2N(CH3)3+ Particle ...