CAS 145-13-1 Pregnenolone


CAS 145-13-1 Pregnenolone

Progesterone Steroids Hormone Pregnenolone Raw Steroids Powder Cas 145-13-1

Product Name: Pregnenolone
CAS:145-13-1
EINECS: 205-647-4
MF: C21H32O2
MW:316.48
MP :188-190 °C
alpha :28.5 o (c=1, EtOH)
Storage temp. : Refrigerator
Categories: Steroids;Steroids&Hormones, Pharmaceuticals
Usage: Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus.

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.

Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Pregnenolone undergoes further steroid metabolism in one of three ways.

Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) using a desmolase. DHEA is the precursor of androstenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.

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Our advantages:
1)Saichuang Technology Co., ltd is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
2)Our products have exported to Germany , Norway , Poland , Finland , Spain , UK , France ,Russia , USA , Australia , Japan , Korea and many other countries, over 100kgs each month.
3)Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK , Norway , Poland , Spain , USA , Canada , Brazil; 98% pass to Germany , Russia , Australia , New Zealand .
4)Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
5)High quality, good price, fast and safety delivery.




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