PW/WFI Storage & Distribution Systems
The purified water generation and distribution systemis the core unit of the whole pharmaceutical water system, and its main function is to ensure that the pressure, flow and temperature delivered to the process pipeline meet the process production requirements. The system uses online monitoring instruments such as flow, pressure, temperature, conductivity and TOC to conduct safety performance, real-time monitoring and trend analysis of water quality, and effectively control the load of microorganisms in water through periodic disinfection or sterilization. In addition, sampling valves shall be installed on the water supply starting point, water pipeline and end pipeline of the entire distribution system for water quality sampling. The whole system is mainly composed of inverter, exchanger, sampling valve, diaphragm valve, sanitary pipe fittings, online monitoring instrument and other supporting control systems.
TYPES OF PURIFIED WATER STORAGE AND DISTRIBUTION SYSTEM
PW Tank/Skid
The purified water storage tank is manufactured according to the GMP certification requirements, and the tank body is vertical or horizontal.
WFI Tank/Skid
The storage tank is mainly used for the storage of water for injection. Meet the requirements of GMP for water for injection storage tank.
PW/WFI Skid
The liquid medicine storage and wfi distribution systemincludes a storage part and a distribution part. The design of pharmaceutical water distribution system has various forms, and its basic idea is to minimize the operational risk and microbial risk at a reasonable cost.
GENERAL PRINCIPLES OF PHARMACEUTICAL WATER STORAGE & DISTRIBUTION SYSTEMS
The storage and distribution system of pharmaceutical water includes storage unit, distribution unit and water point pipe network unit. The design of pharmaceutical water distribution system has various forms, and the basic idea is to minimize the operation risk and microbial risk at a reasonable cost.
The storage unit is used to store pharmaceutical water meeting the requirements of the pharmacopoeia and meet the maximum peak consumption requirements of the system. The storage system must maintain the quality of water supply, so as to ensure that the quality of the end use of the product is qualified.
Circulating design is adopted for the pharmaceutical water supply pipeline.The main function of the distribution system is to deliver pharmaceutical water meeting the requirements of the Pharmacopoeia to the process water point, and ensure that its pressure, flow and temperature meet the requirements of process production or cleaning.
The storage and distribution units need to be disinfected regularly to reduce the possibility of microbial breeding.
HOW IS WATER SYSTEM DISTRIBUTED?
01
PW storage and distribution system
PW storage and purified water distribution systemmust be disinfected regularly. Automatic control mode is recommended. The common disinfection methods for purified water storage and distribution system are as follows: 1. Pasteurization; 2. Ozone disinfection
02
WFI storage and distribution system
WFI storage and distribution systems must be sterilized regularly. Automatic control mode is recommended. Common sterilization methods of WFI storage and distribution system are as follows: 1. Pure steam sterilization; 2. Sterilization with superheated water
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