Dapoxetine hydrochloride/steroidsbio@chembj.com

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Product Name:Dapoxetine hydrochloride
Alias: Dapoxe, Dapoxeti ,Dapoxetinehy, Dapoxetine HCl
CAS No: 129938-20-1 or 119356-77-3
Molecular Formula:C21H24ClNO
Molecular weight:341.88
Purity: 98%
Appearance: White crystalline powder
Grade:Pharmaceutical Grade

Dapoxetine

is the first compound developed specially for the treatment of premature ejaculation (PE) for men between 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, so as to delay consequence ejaculation. As a member of (SSRI) family, Dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, Dapoxetine is absorbed and eliminated rapidly in the body. Its immediate response makes it suitable for the treatment of PE but not as an antidepressant.

Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when Dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence, an increasing adverse effects. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.

Pharmacodynamics

Dapoxetine hydrochloride is a SSRI. The physiology of ejaculation primarily depends on serotonin and dopamine receptors including 5-HT1a and 5-HT2c. Dapoxetine hydrochloride prevents the reuptake of serotonin transporter. The drug binds with the reuptake transporters of norepinephrine and dopamine and inhibits the reuptake.

Dapoxetine Dosage

For premature ejaculation and erectile dysfunctions (Adults):The recommended adult dose of Dapoxetine hydrochloride is 30 - 60 mg/day. The maximum dose should not exceed 100 mg/day. Take Dapoxetine hydrochloride at least two hours before sexual intercourse to achieve maximum treatment benefits.




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