Mifepristone

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Name:
Mifepristone 
Molecular Formula:
C29H35NO2
CAS Registry Number:
84371-65-3
Synonyms:
Estra-4,9-dien-3-one,11-[4-(dimethylamino)- phenyl]-17-hydroxy-17-(1-propynyl)-,(11a,- 17a)-; Mifepristone [USAN:BAN:INN]; 17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one; Mifeprex; Mifepristonum [Latin]; R 38486; RU 38486; 11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on; Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-, (11b,17b)-; Prestwick_570; Mifegyne; (11beta,17beta)-11-(4-(Dimethylamino)-phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; RU-486; RU486; 11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on; RU 486-6; 17-(1-propynyl)estra-4,9-dien-3-one;
InChI:
InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
Molecular Structure:
Mifepristone C29H35NO2 (cas 84371-65-3) Molecular Structure
This structure is also available as a 2d Mol file

Chemical Properties

Appearance:
Pale Yellow Solid
Molecular Weight:
429.5937
Density:
1.18 g/cm3
Boiling Point:
628.6 °C at 760 mmHg
Melting Point:
195-198°C
Flash Point:
334 °C
Storage Temperature:
2-8°C
Refractive index:
1.623
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Biological Activity:
Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.
Stability:
Stable at normal temperatures and pressures.
Usage:

A progesterone receptor antagonist with partial agonist activity. Abortifacient.



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