Sunifiram DM-235 white crystalline powder 1-benzoyl-4-propanoylpiperazine Sunifiram DM-235

Sunifiram DM-235 white crystalline powder 1-benzoyl-4-propanoylpiperazine Sunifiram DM-235
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Keywords: Sunifiram, DM-235, Sunifiram DM-235, Hongkong Shijingu Technology Co Ltd

1. Specification (Manufacturer supply directly)
Sunifiram Product Name Sunifiram (DM-235)
Sunifiram Synony 1-benzoyl-4-propanoylpiperazine
Sunifiram Molecular Formul C14H18N2O2
Sunifiram Molecular Weight 246.304
Sunifiram CAS No. 314728-85-3
Sunifiram Purity 99.8%
Sunifiram Melting point 94.5°C-95.5°C
Sunifiram Appearance Off-white to white crystalline powder

2. Introduction
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric
modulator of AMPA receptors, and has nootropic effects in animal studies with significantly
higher potency than piracetam. A number of related compounds are known, the best known
being unifiram (DM-232)

This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.

3. Function
1.Sunifiram activates AMPA-mediated neurotransmission.
2.Enhancing LTP in a bell-shaped dose-response relationship.
3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.



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