Lorcaserin hydrochloride

CAS 846589-98-8 Lorcaserin hydrochloride

Product Name: Lorcaserin hydrochloride
Synonyms: Lorcaserin HCl
MF: C11H14ClNClH
MW: 232.1525
CAS: 846589-98-8

Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development,is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.

Lorcaserin is used long term for weight loss in those who are obese.BELVIQ is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.

Lorcaserin VS Orlistat

Lorcaserin is a selective 5-HT2C receptor agonist,and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety.The safety and effectiveness was tested in the 3 clinical trials which nearly 8000 overweight or obese participants were involved.

Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces. But for a part of stubborn obesity who get good appetite, the treatment effect is not ideal.


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