Fertirelin Acetate

Product Name Fertirelin Acetate
Sequence Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
Cas No. 38234-21-8
Molecular Formula C55H76N16O12
Molecular Weight 1153.26
Purity (HPLC) 99.0%
Appearance? White powder
Single Impurity(HPLC)? 1.0%
Amino Acid Composition? 10% of theoretical
Peptide Content(N%) 80%(by %N)
Water Content(Karl Fischer)? 6.0%
Acetate Content(HPIC) 15.0%
MS(ESI)  
Mass Balance? 95.0~105.0%



Detailed Product Description

Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and it is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus. The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group.



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