Pharmaceutical Raw Materials Guaifenesin CAS 93-14-1

Pharmaceutical Raw Materials Guaifenesin CAS 93-14-1


Basic Info.

Name:Guaifenesin
Synonyms:3-(2-Methoxyphenoxy)-1,2-propanediol; Guaiacol glyceryl ether; Glycerol guaiacolate
Molecular Formula:C10H14O4
Molecular Weight:198.22
CAS Registry Number:93-14-1
EINECS:202-222-5
Melting point:77-81 ºC
Boiling point:215 ºC (19 mmHg)
Water solubility:5 g/100 mL (25 ºC)


Usage:

Expectorant cough, phlegm cough for chronic bronchitis, bronchiectasis and other illnesses
Guaifenesin or guaiphenesin (former BAN), also glyceryl guaiacolate,is an expectorant drugsold
over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from
the airways in acute respiratory tract infectiion.


Effect and mechanism of action

Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. It also stimulates the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the pharynx.Thus, it may increase the efficiency of the cough reflex and facilitate removal of the secretions; however, objective evidence for this is limited and conflicting.

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