Afoxolaner

Afoxolaner for dogsis used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Gihi Chemicalsalso has afoxolaner for cats. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. When afoxolaner is prescribed for the treatment of mange, it is referred to as "extra label" or "off label" use.

Afoxolaner Synonym

4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide; Afoxolaner; 1-NaChemicalbookphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2, 2, 2-trifluoroethyl)amino]ethyl]-; Afoxolanerfandachem

Afoxolaner Safety

CAS No.:

EC No.: 832-051-7

MF: C26H17ClF9N3O3

MW: 62.587

Parameters of Afoxolaner

Item	Specification	Results
Appearance	White To Off-white Crystalline Powder	Complies
Identification	HPLC: HPLC Retention Time Confirms To Standard	Complies
Melting Point	148-155℃	148-150℃
Water	≤0.1%
Residue Solvents	Dichloromethane≤600ppm
	Isopropyl Acetate≤5000ppm
	Isopropanol≤890ppm	2ppm
	N, N-Dimethylformamide≤880ppm
	Methanol≤3000ppm
	Tetrahydrofuran≤720ppm
	Triethylamine≤5000ppm
Residue On Ignition	≤0.1%
Related Substances	Impurity D≤0.15%
	Impurity F≤0.15%
	Individual Unknown Impurity≤0.10%
	Total Impurities≤1.00%
Assay(Anhydrous Substance)

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Packing:

100g/bag; 500g/bag; 1kg/bag

Recommended storage method:

Store in a cool, dry and ventilated place.

Recommended storage temperature:

2 - 8 °C

Product usage:

Pharmaceutical intermediates

Benefits of Afoxolaner

Treat and control flea and tick infestations in dogs.

When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.

The treatment of sarcoptic mange or demodectic mange.

When afoxolaner is prescribed for the treatment of mange, it is referred to as 'extra label' or 'off label' use.

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