CAS 50-50-0 Estradiol benzoate


CAS 107724-20-9 Eplerenone

Chemical Name: Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma- lactone methyl ester
CAS NO.: 107724-20-9
Molecular Formula: C24H30O6
Molecular weight: 414.49
Appearance: white crystalline powder; slightly soluble in water.
Standard: Enterprise Standard

Eplerenone is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, or estrogenic effects), and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. It was marketed by Pfizer under the trade name Inspra but is now only available as a generic in every country except the United Kingdom. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.

Eplerenone is specifically indicated for the reduction of risk of cardiovascular death in people with heart failure and left ventricular dysfunction within 3-14 days of an acute myocardial infarction, in combination with standard therapies and as treatment against hypertension. It appears equivalent to spironolactone but is much more expensive.

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