SHFM1 Antibody

Product Name:
SHFM1 Antibody
Code : CSB-PA021263LA01HU
Uniprot NO. : P60896
Storage : Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Immunogen : Recombinant human 26S proteasome complex subunit DSS1 protein
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA;Not yet tested in other applications.
Relevance : Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
Form : Liquid
Conjugate : Non-conjugated
Storage Buffer : Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification method : >95%,Protein G purified
Isotype : IgG
Clonality : Polyclonal
Alias : 26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein,SHFM1,DSS1,SHFDG1
Species : Human



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