Rat Huntingtin (HTT) ELISA kit

Product Name:
Rat Huntingtin(HTT) ELISA kit
Product Type : ELISA Kit
Code : CSB-EL010905RA
Size : 96T,5×96T,10×96T
Uniprot NO. : P51111
Abbreviation : HTT
Alias : HD, IT15,
Species : Rat
Sample Types : serum, plasma, tissue homogenates, cell lysates
Detect Range : 28.12 pg/ml-1800 pg/ml
Sensitivity : 7.03 pg/ml
Assay Time : 1-5h
Sample Volume : 50-100ul
Availability : 7-14 working days
Research Area : Cell Biology
Protocol :
Instructions
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target details : Huntingtin is a disease gene linked to Huntington s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington s disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5 UTR that inhibits expression of the huntingtin gene product through translational repression.



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