Recombinant human HLA class II histocompatibility antigen, DP beta 1 chain prote

Product Name:
Recombinant human HLA class II histocompatibility antigen, DP beta 1 chain prote
Product Type : Recombinant Protein
Code : CSB-RP148094h
Size : 1mg
Uniprot NO. : P04440
Research Area : Immunology
Source : E.coli
Gene Names : HLA-DPB1 HLA-DP1B
Expression Region : 30-225aa
Product Info : His-tag
Mol. Weight : 26.6kD
Protein Description : Extracellular domain
Target details : HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

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