Human 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(CYP27B1) ELISA kit

Product Name:
Human 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(CYP27B1) ELISA kit
Product Type : ELISA Kit
Code : CSB-EL006406HU
Size : 96T,5×96T,10×96T
Uniprot NO. : O15528
Abbreviation : CYP27B1
Alias : CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, 1alpha(OH)ase|25 hydroxyvitamin D3-1-alpha hydroxylase|25-Hydroxyvitamin D3 1alpha-hydroxylase|25-OHD-1 alpha-hydroxylase|25-hydr
Species : Human
Sample Types : serum, plasma, tissue homogenates, cell lysates
Detect Range : 31.25 pg/ml-2000 pg/ml
Sensitivity : 7.81 pg/ml
Assay Time : 1-5h
Sample Volume : 50-100ul
Detection Wavelengt : 450 nm
Availability : 7-14 working days
Research Area : Others
Protocol :
Instructions
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Target details : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

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