Recombinant human Alkaline phosphatase, tissue-nonspecific isozyme

Product Name:
Recombinant human Alkaline phosphatase, tissue-nonspecific isozyme
Product Type : Recombinant Protein
Code : CSB-YP001631HU >> Yeast
CSB-EP001631HU >> E.coli
CSB-BP001631HU >> Baculovirus
CSB-MP001631HU >> Mammalian cell
Size : 1mg
Uniprot NO. : P05186
Storage : Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
Storage Buffer : Tris-based buffer,50% glycerol
Expression Region : 18-502
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Target details : There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

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