Recombinant Mouse Neuroendocrine secretory protein 55(Gnas)

Product Name:
Recombinant Mouse Neuroendocrine secretory protein 55(Gnas)
Product Type : Recombinant Protein
Code : CSB-YP897066MO >> Yeast
CSB-EP897066MO >> E.coli
CSB-BP897066MO >> Baculovirus
CSB-MP897066MO >> Mammalian cell
Abbreviation : Gnas
Storage Buffer : Tris-based buffer,50% glycerol
Species : Mus musculus (Mouse)
Gene Names : Name:Gnas Synonyms:Gnas1
Protein Names : Recommended name: Neuroendocrine secretory protein 55 Short name= NESP55 Cleaved into the following 2 chains: 1. LHAL tetrapeptide 2. GPIPIRRH peptide
Expression Region : 47-257
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Product Info : His tagged
Protein Description : full length protein

Target details : This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts contains a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

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