Sorafenib tosylate

Sorafenib tosylate
Chemical Name: 4 - {4 [3 - (4-chloro-3-trifluoromethyl-phenyl) ureide] phenoxy} pyridine-2-carboxamide p-toluenesulfonate
Product Alias: toluenesulfonic sorafenib mesylate Sorafenib Sorafenib p-toluenesulfonic
English name: Sorafenib tosylate
English Synonyms: Sorafenib (Nexavar)
CAS: 475207-59-1
Keywords: Sorafenib tosylate, sorafenib tosylate, mesylate Sorafenib, 475207-59-1
Molecular formula: C21H16ClF3N4O3.C7H8SO3
Molecular Weight: 637.03
Appearance: yellow or white crystalline powder
Melting point: 225-235 ℃
Loss on drying: Less than 0.5%
Heavy metals: Less than 10ppm
Total impurities: less than 1.0%
Content: 99%
Packing: 1kg / aluminum foil bag
Uses: toluenesulfonic Sorafenib is a novel multi-target anticancer drugs, can act simultaneously on tumor cells and tumor blood vessels. It has a dual anti-tumor effects: either by blocking the RAF / MEK / ERK-mediated cell signaling

Pathway directly inhibit the proliferation of tumor cells, but also by inhibiting VEGF and platelet-derived
Health growth factor (PDGF) receptors and block the formation of tumor angiogenesis, indirectly inhibit the growth of tumor cells.



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