CAS 86386-73-4 Fluconazole

CAS 137234-62-9 Voriconazole

Producyt Name: Voriconazole
CAS: 137234-62-9
MF: C16H14F3N5O
MW: 349.31
Purity: 99%
Melting Point: 127-130°C
Grade: Pharmaceutical Grade
Appearance: White Powder

Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.

Invasive Aspergillosis

Voriconazole is used to treat invasive aspergillosis, which may occur in immunocompromised patients, including allogeneic BMT, hematologic cancers, and solid organ transplants.

For multiple site or CNS aspergillosis a combination therapy of voriconazole and caspofungin should be considered. It is also the recommended treatment for the CNS fungal infections transmitted by epidural injection of contaminated steroids.

Candidemia

Voriconazole has proven to be as effective as a regimen of IV amphotericin B followed by oral fluconazole in patients with culture-proven candidemia. Voriconazole cleared Candida from the bloodstream as quickly as amphotericin B (median 2 days) and showed a trend toward better survival. Voriconazole was also associated with fewer serious adverse events and cases of renal toxicity, but a higher incidence of visual disturbances.

Voriconazole was also proven to offer similar, near-complete efficacy to fluconazole in the treatment of esophageal candidiasis.



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