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CAS 2398-96-1 Tolnaftate

Product Name: Tolnaftate
CAS: 2398-96-1
MF: C19H17NOS
MW: 307.41
Assay: 99.5%
Melting Point: 110.5-111.5
Loss on Drying: 0.03%
Usage: Antifungal Agents
Medicine Grade: Antifungal Agents
Appearance: White or Yellowish Powder

Solubility: <0.1 g/100 mL at 22
HazardClass: IRRITANT
Residue On Lgnition: 0.01%
Heavy Metals: ≤ 0.002%

Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.

Mechanism

Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal membrane) in a similar way to allylamines.

Uses

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.



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