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CAS 42924-53-8 Nabumetone

Product Name: Nabumetone
Alias: Relafen,Relifex
CAS: 42924-53-8
MF: C15H16O2
MW: 228.29
Assay: 99%
Usage: Non steroidal anti-inflammatory drug (NSAID)
Grade:Pharmaceutical Grade
Appearance: White Or Almost White Crystalline Powder

Nabumetone is a non-steroidal anti-inflammatory drug, the only 1-naphthaleneacetic acid derivative. Nabumetone has been developed by Beecham. It is available under numerous brand names, such as Relafen, Relifex, and Gambaran.

It is used to treat pain or inflammation caused by arthritis or other inflammatory diseases and conditions like synovitis. Nabumetone works by reducing the effects of enzymes that cause pain and inflammation.

Nabumetone is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). The active metabolite of nabumetone is felt to be the compound primarily responsible for therapeutic effect. Comparatively, the parent drug is a poor inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin.



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