CAS 59122-46-2 Misoprostol Product Name: Misoprostol CAS: 59122-46-2 MF: C22H38O5 MW: 382.54 MP: 261-263°C HS Code: 3001200010 Purity: 98% Package: 1kg/aluminium foil bag Appearance: White Solid Bio

CAS 15574-96-6 Pizotifen

Product Name: Pizotifen
Synonyms: Sandomigran,Sanomigran
CAS: 15574-96-6
EINECS: 239-632-9
MF: C19H21NS
MW: 295.4417
Assay: 98%
Appearance: White Powder

The main medical use for pizotifen is for the prevention of vascular headache including migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid and amitriptyline. While pizotifen is reasonably effective, its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative when other drugs have failed to be effective. It is not effective in relieving migraine attacks once in progress. Pizotifen has also been reported as highly effective in a severe case of erythromelalgia, a rare neurovascular disease that is sometimes refractory to the other drugs named above.

Other applications for which pizotifen may be used include as an antidepressant, or for the treatment of anxiety or social phobia. Animal studies also suggest that pizotyline could be used in the treatment of serotonin syndrome or MDMA overdose in a similar manner to the closely related antihistamine/antiserotonin drug cyproheptadine.

Usage:
Pizotifen called new degree Semillon, pizotifen malate, is a chemical synthetic antihistamines, its chemical structure is similar cyproheptadine and amitriptyline, has strong anti 5- serotonin and histamine and weak anti acetylcholine effect, one of the commonly used drugs for the prevention of migraine.
1. this product is inhibition of bradykinin (BK) on the peripheral nerve pain induced sedation, and antidepressant effect.
2. this product can reduce the ethanol tolerance, can strengthen the tranquilizer, sedative and tricyclic antidepressant effect.
Clinical mainly for typical and atypical migraine, can relieve a symptom, reduce seizure frequency and duration, obvious curative effect on acute migraine, but no immediate relief, also be tried in erythromelalgia, angioneurotic edema, chronic urticaria, skin Nick disease etc.. Another report, pizotifen for carcinoid syndrome caused by diarrhea and flushing, carotid pain, polycythemia induced pruritus



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