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CAS 148553-50-8 Pregabalin

Product Name: Pregabalin,Lyrica
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Purity: 99%
Application: Anti-Epileptic Drug Pharmaceutical Intermediates
Function: Blood System Agents
Grade Standard: Pharmaceutical Grade
Appearance: White Or Almost White Crystalline Powder

Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults.It has also been found effective for generalized anxiety disorder,it was designed as a more potent successor to gabapentin

Pregabalin also known as β-isobutyl-γ-Aminobutyric acid (β-isobutyl-GABA) and sold under the brand name Lyrica is a medication primarily used for epilepsy, neuropathic pain, and fibromyalgia.Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.It is also considered useful for generalized anxiety disorder.

Pregabalin is a derivative of the naturally occurring inhibitory neurotransmitter γ-Aminobutyric acid (GABA) and classified as a depressant by the Drug Enforcement Agency.It is a neurotransmitter modulator that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating properties. Pregabalin is a potent gabapentinoid and a close structural analogue of GABOB (β-hydroxy-GABA), baclofen (β-(4-chlorophenyl)-GABA), and phenibut (β-phenyl-GABA)

Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.

Pregabalin Is Indicated For:

1.Treatment of neuropathic pain from diabetic neuropathy or post herpetic neuralgia. There is not enough data to state that it should be used in all neuropathic pain.
2.Adjunctive therapy in adults with partial seizures with or without secondary generalization
3.Fibromyalgia
4.Generalized anxiety disorder
5.Alcohol Withdrawal
Usually physicians will start the patient on a low dose of pregabalin and increase it gradually, depending on the patient's evaluation. Its therapeutic effect appears after 1 week of use and is similar in effectiveness to lorazepam, alprazolam and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Side Effects

Common side effects include: sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problem with vision, and weight gain.Potentially serious side effects include angioedema, drug misuse, and an increased suicide risk.



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