CAS 507-70-0 Borneol

CAS 51-05-8 Procaine HCl

Product Name: Procaine HCl
Alias: Procaine Hydrochloride,Aminocaine,Anadolor,Atoxicocaine,Neocaine,Procaine Hydrochlo,Procaine
CAS: 51-05-8
EINECS: 200-077-2
MF: C13H21ClN2O2
MW: 272.77
Melting Point: 155-156 °C
Assay: 99%
Grade: Pharmaceutical Grade
Appearance: White Crystalline Powder


Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

Side Effects

Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase,which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.


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