CAS 507-70-0 Borneol

CAS 9004-34-6 Cellulose Microcrystalline

Product Name: Microcrystalline Cellulose
Alias: Microcrystalline,Emcocel,Crocrystalline-Cellulos,MCC
CAS: 9004-34-6
EINECS: 232-674-9
MF: (C6H10O5)n,n≈220
MW: about 36000
Content: 99%
Appearance: White Crystalline Powder

Microcrystalline Cellulose exhibits excellent properties as an excipient for solid dosage forms. It compacts well under minimum compression pressures, has high binding capability, and creates tablets that are extremely hard, stable, yet disintegrate rapidly. Other advantages include low friability, inherent lubricity, and the highest dilution potential of all binders. These properties make Microcrystalline Cellulose particularly valuable as a filler and binder for formulations prepared for direct compression. Also, it has proven to be stable, safe and physiologically inert.

MCC is generally considered as the diluent having the best binding properties and is recognized as one of the preferred direct compression binders . In addition to its dry binding properties, and in comparison to brittle excipients, MCC is self-disintegrating with low lubricant requirement due to its extremely low coefficient of friction and its very low residual die wall pressure .However these properties do not replace the need for true disintegrants and lubricants when MCC is used in a formulation. In fact MCC and superdisintegrants may be complementary to promote fast disintegration. MCC offers other advantages including broad compatibility with APIs, physiological inertness, ease of handling, and security of supply.

Microcrystalline Cellulose is a naturally occurring substance proven to be stable, safe and physiologically inert. Microcrystalline Cellulose is cellulose derived from high-quality wood pulp. While cellulose is the most abundant organic material in the pulp, microcrystalline cellulose can only be derived from alpha cellulose.

Microcrystalline cellulose revolutionized tabletting because of its unique characteristics. It exhibits excellent properties as an excipient for solid dosage forms. It compacts well under minimum compression pressures and offers high binding capacity. It enables production of tablets that are extremely hard and stable, and yet which can disintegrate rapidly when consumed. Other advantages include low friability, inherent lubricity, and the highest dilution potential of all binders. These properties make microcrystalline cellulose particularly valuable as a filler and binder for formulations prepared by direct compression, although it also is used in wet or dry granulation.



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