pharmaceutical excipient: methyl-beta-cyclodextrin

Name: methyl-beta-cyclodextrin Other name : methyl-β-cyclodextrin CAS: 128446-36-6 Abbreviation: MEBCD Molecular formula : C42H70-nO35 · (CH3)n Molecular weight: 1135 + n·(14.0) Solubility(in 100cm3 solvent, at 25℃) : water: >50g Methanol: >50g Chloroform: ~ 2 g Standard : enterprise standard Package: 500g/bag , 1kg/bag, 10kg/drum Use : medical chemical other industries Description Appearance white powder, insipid, innocent Qualify Assay ≥98% 99.6% Degree of Substitution 11.2-13.3 13.0 Molar of substitution 1.6-1.9 1.8 Loss on Drying ≤5.0% 3.9% Optical density of a 10%solution (220-350nm) ≤1.0 Qualify Optical density of a 10%solution (350-600nm) ≤0.1 Qualify Chloride ≤0.2% ≤0.05% Unsubstituted cyclodextrin ≤0.3% Absent Residue on Ignition ≤0.5% 0.39% Heavy Metal (as pd) ≤0.0001% <0.0001% Arsenic salt (AS) ≤0.0005% <0.0005% Specific rotation 154-165º 156.2º Solubility in water(25℃) >750g/L Qualify TAMC(cfu/g) ≤1000 10 TYMC(cfu/g) ≤100 10 Salmonella/E. Coli (cfu/g) Absent Absent Storage: at room temperature, in tightly closed container. Characteristics and applications: Methylated-β-cyclodextrin (Me-β-CD) is one of cyclodextrin derivatives that were widely used in modern researches and applications. Me-β-CD can be soluble both in water and in organic solvents. In pharmaceuticals industry, it can increase solubility and bioavailability of drugs, so that the efficacy of drugs can last longer with less ingestion. It can adjust and control the drug release rate, reduce drug side-effects, and enhance the stability of drugs particularly for oil-soluble molecules. In commodity chemicals and cosmetics, Me-β-CD can reduce microbial contamination and skin irritations, keep skin moist, mask bad odors, promote transdermal absorption of activeingredients. Me-β-CD has a larger surface tension in common cyclodextrin derivatives.


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