Omeprazole

Omeprazole

CAS: 73590-58-6

Assay: 98.5% min. CP

Packing: 20Kg/cardboard drum

MF: C17H19N3O3S

MW: 345.42

Character: White Crystalline Solid. mp 156°C. solubility H2O: 0.5 mg/mL

Usage: Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative pharmaceutical raw materials.

Biological Activity: H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).



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