Salbutamol

Salbutamol ,Fat Loss Steroids / Romilar / Assay 99.53% CAS 51022-70-9

Quick Detail:

 Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease.

 Description:

Albuterol Sulfate

Alias: Salbutamol; Ventolin;  Proventil

CAS No: 51022-70-9

EINECS No: 242-424-0

MF: (C13H21NO3)2·H2SO4

MW: 576.71

 

 

Purity: 99.5%

Appearance: White powder, soluble in the water and  ethanol .

Applications:

It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.

Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.

Specifications: 

Test Items

Specification

Test Results

Appearance

white oralmost white,crystalline powder

Conform

Solubility

Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.

Conform

Identification

A

The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.

Conform

B

Infraed absorption spectrophotometry.

Conform

C

Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.

Conform

D

An orange-red color develop in methylene chloride layer.

Conform

E

It geves reaction (a) of sulphates.

Conform

Appearance of solution

Solution S is clear and not more intensely coloured than reference solution in BY6.

Conform

Optical rotation

﹣0.10° to +0.10°determined on solution S.

+0.01°

Acidity or alkalinity

NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.

Conform

Related substances

Impurity J ≤0.20%

Conform

Any other impurity ≤0.30%

Conform

Total impurity ≤1.0%

Conform

Boron

≤50ppm

Conform

Sulphated ash

≤0.10%

 

Loss on drying

≤0.5%

 

Assay(on dried basis)

   

Conclusion

The test results above BP2009

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