Tadalafil Citrate CAS No: 171596-29-5

Quick Detail:

 

Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension.

 

 

Description:

 

Tadalafil Citrate

Alias: Tadalafei;Cialis

CAS No: 171596-29-5

MF: C22H19N3O4

MW: 389.41

 

 

Purity: 99.5%

Appearance: white powder, odorless, tasteless, insoluble in water and alcohol.

 

 

Applications:

 

 

Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.

 

 

Specifications:

 

 

Test Items

Specification

Test Results

Appearance

White powder

Conforms

Test method

High pressure liquid chromatography(HPLC)

Conforms

Melting Point

300℃~303℃

  1. ℃-302.6℃

Loss on drying

≤0.5%

 

Heavy metals(Pb)

≤20ppm

 

Residue on ignition

≤0.1%

 

Relative substance

≤1.0%

 

Assay (on dried basis)

≥98.5%

 

Conclusion

The product conform to USP 32.

 

 

 

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