Dehydroepiandrosterone DHEA

white endogenous estrogen metabolite steroid raw materials 2 - methoxy estradiol 98%

Quick Detail:
2 - methoxy estradiol
Product name: 2 - methoxy estradiol
CAS NO:. 362-07-2
Minor: C19H26O3
Content: 98%
Packing: 1 kg aluminum foil bag
usage: steroid raw materials


2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated:. potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1 pseudo itself. 2-Methoxyestradiol has been shown to induce apoptosis through activation of the p53 pathway through either activation of p38 and NF-B or JNK and AP-1 both leading to Bcl-2 phsophorylation. In addition the compound has also been observed to upregulate death receptor 5 and bind to tubulins.


2-Methoxyestradiol exhibits potent apoptotic activity against rapidly growing tumor cells. It also possesses antiangiogenic activity through a direct apoptotic effect on endothelial cells. Other molecular mechanisms, including microtubule stabilization by inhibition of the colchicine-binding site, have been reported. The exact mechanism of action of 2-methoxyestradiol is still unclear, but it has been shown to be effective in preventing tumor growth in a variety of cell lines. 2-Methoxyestradiol also possesses cardioprotective activity by inhibiting vascular smooth muscle cell growth in arteries. It has a lower binding affinity for estrogen receptor alpha compared with that of estradiol, and its affinity for estrogen receptor beta is even lower than that of estrogen receptor alpha, thus it has minimal estrogenic activity. 2-Methoxyestradiol is distinct because of its inability to engage estrogen receptors as an agonist, and its unique antiproliferative and apoptotic activities are mediated independently of estrogen receptors alpha and beta.


至: 湖北远程有限公司
Your E-mail:

Send to other suppliers

Other supplier products

Testosterone Enanthate (Steroids)
Testosterone Enanthate (Steroids)
Testosterone Acetate
Testosterone Acetate
Nandrolone Decanoate
Nandrolone Decanoate
Boldenone Acetate
Boldenone Acetate
Boldenone Acetate
Boldenone Acetate

Same products

Anesthetic Agents 98.5% L-Tryptophan
Anesthetic Agents 98.5% L-Tryptophan 卖方: HEBEI VICTORIA IMP.&EXP.CO.,LTD.
Pharmaceutical Grade L-THREONINE,Essential Amino Acid L-THREONINE
Pharmaceutical Grade L-THREONINE,Essential Amino Acid L-THREONINE 卖方: HEBEI VICTORIA IMP.&EXP.CO.,LTD.
Feed Grade Amino Acids DL METHIONINE 59-51-8
Feed Grade Amino Acids DL METHIONINE 59-51-8 卖方: HEBEI VICTORIA IMP.&EXP.CO.,LTD.
Feed Grade L-Lysine Sulphate 70%
Feed Grade L-Lysine Sulphate 70% 卖方: HEBEI VICTORIA IMP.&EXP.CO.,LTD.