Factory Direct Hot Sale Tacrolimus CAS:104987-11-3 Good price

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Tacrolimus Basic information
Product Name:Tacrolimus
Synonyms:(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
CAS:104987-11-3
MF:C44H69NO12
MW:804.02
EINECS:
Product Categories:Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic
Tacrolimus Chemical Properties
mp 113-115°C
storage temp. ?20°C
solubility DMSO: >3 mg/mL
form solid
color white
Tacrolimus Usage And Synthesis
Chemical PropertiesWhite Crystalline Solid
UsageAn immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
UsageFK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
UsageTacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.
Usagetreatment of Cushing's syndrome
UsageFor use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart

Fob Price Negotiable
Brand Nanjian
Min Order 10 Grams
Place of Origin China
Certifications ISO9001:2008/Kosher Certificate/SGS
Package As Your Request with Discreet Package way
Guarantee
Delivery Timely

Pass the Customs

Capacity 500-800Kgs/Month
Port Shang Hai,Shen Zhen,Hong Kong
Payment Western Union,T/T, MoneyGram
Shipment FOB,CIF,EMS,DHL,FEDEX

 



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