CAS 145-13-1 Pregnenolone/

Product Name: Pregnenolone
EINECS: 205-647-4
MF: C21H32O2
MP :188-190 °C
alpha :28.5 o (c=1, EtOH)
Storage temp. : Refrigerator
Categories: Steroids;Steroids&Hormones, Pharmaceuticals
Usage: Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus.

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.

Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Pregnenolone undergoes further steroid metabolism in one of three ways.

Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) using a desmolase. DHEA is the precursor of androstenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.


至: Yuancheng(HK) Pharmaceutical Co.,Ltd
Your E-mail:

Send to other suppliers

Other supplier products

Pharmaceutical materials
CAS 145-13-1 Pregnenolone/
CAS 72-63-9 Metandienone ,Dianabol /
CAS 846-48-0 Boldenone
CAS 846-48-0 Boldenone
CAS 72-63-9 Metandienone ,Dianabol /

Same products

卡格列净 卖方: 杭州慧生生物医药科技有限公司 质量标准:内部控制   CAS 编号:842133-18-0
达格列净 卖方: 杭州慧生生物医药科技有限公司 质量标准:内部控制   CAS 编号:461432-26-8
枸橼酸托法替布 卖方: 杭州慧生生物医药科技有限公司 质量标准:内部控制   CAS编号:540737-29-9
阿哌沙班 卖方: 杭州慧生生物医药科技有限公司 质量标准:内控质量标准   CAS 编码:503612-47-3
阿哌沙班 卖方: 杭州慧生生物医药科技有限公司 质量标准:内控质量标准   CAS 编码:503612-47-3