Light Yellow MGA Megestrol Acetate 99% 2919-66-6 Crystalline Powder

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Light Yellow MGA Megestrol Acetate 99% 2919-66-6 Crystalline Powder

1. Quick Details:
Melengestrol acetate
Product name: Melengestrol acetate
Synonyms: 0-dione, 17-(acetyloxy)-6-methyl-16-methylene-pregna-6-diene-3; 6-dehydro-16-methylene-6-methyl-17-acetoxyprogesterone;
CAS Registry Number: 2919-66-6
Assay: 98%
Molecular Formula: C25H32O4
Molecular weight: 396.52
Appearance: Light yellow crystalline powder

Product Name Melengestrol Acetate
Synonyms Melengestrol Acerate; 6-methyl-16-methylidene-3,20-dioxopregna-4,6-dien-17-yl acetate
Molecular Formula C25H32O4
Molecular Weight 396.5192
CAS Registry Number 2919-66-6
EINECS 220-859-7
Molecular Structure
Density 1.15g/cm3
Melting point 202-204¡æ
Boiling point 516.1¡ãC at 760 mmHg
Refractive index 1.554
Flash point 221.7¡ãC
Vapour Pressure 9.29E-11mmHg at 25¡ãC


2. Description:
MGA suppressed estrus and ovulation, and resulted in the presence in the ovary, after regression of corpora lutea, of an increased number of large follicles. The largest follicles corresponding in structure to developing proestrous, mature estrous, or early atretic follicles contained hypertrophied theca interna cells showing lipid secretion signs and ultrastructural characteristics of steroid synthesis. The majority of the largest follicles, however, were atretic or late atretic and did not contain steroid-type cells. The development of replacement follicles was evident in ovaries with late atretic largest follicles. The weight-gain effect of MGA may therefore be associated with a steroidogenic, probably estrogenic, effect in the cow.

3. Applications:
Melengestrol acetate, sometimes abbreviated as MGA, is a steroidal progestin and antineoplastic agent. It is not approved for use in humans, and is instead used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada. It is an acetate ester of melengestrol, which in contrast, is not used in either animals or humans.
A synchronization regime involves combining the effects of melengestrol acetate (MGA), a progestogen-like compound, with PGF2a. When administered in the feed at a level of. 5 mg. Per head per day, MGA is very effective at preventing cows from coming into heat. When PGF2a is administered following MGA removal, cows experience a tightly synchronized estrus.

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