Product name: 17A-hydroxyprogesterone
Synonyms: 17-Alpha-Hydroxy-Progesterone
CAS : 68-96-2
Packaging: 1kg/bag
Assay: 99%
Molecular Formula: C21H30O3
Molecular weight: 330.47
Appearance: White or white crystalline powder

The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group of inherited disorders caused by specific gene mutations and associated with cortisol-related enzyme deficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also called P450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood.

The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or to confirm a CAH diagnosis in people with symptoms.

17-OHP testing may produce false-positive test results. If the level is elevated but not so high that it is diagnostic of CAH, other tests may be performed, such as androstenedione and testosterone. An ACTH stimulation test may be also be ordered as a follow-up test (in CAH, ACTH stimulation will markedly increase 17-OHP levels). Molecular genetic testing may be performed to detect CYP21A2 gene mutations thatcan cause the condition. A karyotype test may be ordered as a follow-up test to detect chromosome disorders and to help determine a baby's sex. Electrolytes may be ordered to measure the person's sodium and potassium levels.

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